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Title   유암 환자에 있어서 c-erbB-2 단백 과발현과 림프절 전이 종양의 크기 , 병기 , 나이 및 생존율과의 관계 ( Correlation of c-erbB-2 Protein Overexpression in Human Breast Carcinoma with Nodal Status , Tumor Size , Stage , Age and Survival )
Publicationinfo   1991 Jan; 023(01): 20-48.
Key_word   Breast carcinoma, c-erbB-2 protein, Immunohistochemical staining
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Abstract   As prognostic indicators of breast carcinoma, axillary lymph nodal status, tumor size, hormone receptor status and nuclear grade have been identified. Their correlation with c-erbB-2 protein overexpression has been controversial. Paraffin-embedded tumor sections, availabe from 48 breast carcinomas, were stained with c-erbB-2 specific antibody. The correlation between strong positive staining and prognostic indicators was anlyzed. 31% (15 of 48) of the tumors were stained strong positively. There was a statistically significant correlation between c-ernB-2 protein overexpression and positive nodal status or staging (p<0.05). In conclusion, the immuno-histochemical staining of c-erbB-2 protein might be used as a versatile tool predicting the prognasis in breast carcinoma.
저 자   김병식(Byung Sik Kim),노동영(Dong Young Noh),최국진(Kuk Jin Choe),이건국(Kuhn Kuk Lee),박성희(Seong Hoe Park),용일(Yong Il Kim),박주배(Joo Bae Park)